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. 2013 Sep 5;9(9):e1003750. doi: 10.1371/journal.pgen.1003750

Figure 2. The regulatory element containing the TT>A variants demonstrates enhancer activity.

Figure 2

Sequences carrying risk (-A) and non-risk (TT) polymorphisms were cloned upstream of a minimal thymidine kinase promoter luciferase construct to measure luciferase activation following transient transfection and stimulation. a. HEK293T cells stimulated with P/I for 48 hours. b. THP1 cells stimulated with LPS for 48 hrs. c. THP1 cells stimulated with P/I for 48 hours. Statistical comparisons were performed using a Student's t-test of three biological independent experiments, * indicates p<0.05.