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. 2013 Sep 5;8(9):e71935. doi: 10.1371/journal.pone.0071935

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© 2013 Visagie et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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LDH levels of ESE-15-one, EMBS and ESE-16 -treated HeLa cells and vehicle-treated control cells after 24 h exposure. The background control consists of growth medium only. The low control refers to cells resuspended in growth medium and the high control to cells resuspended in growth medium with cell lysis solution added to the cells shortly before the experiment was terminated (according to the manufacturer's instructions). No statistically significant increase in LDH levels was observed in treated cells. These results showed that the sulphamoylated compounds were not toxic to the cells.