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. 2013 Sep 5;8(9):e71935. doi: 10.1371/journal.pone.0071935

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© 2013 Visagie et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Caspase 8 and caspase 6 activity ratios of compound- and actinomycin D-treated cells compared to vehicle-treated cells. Caspase 6 and caspase 8 activities in all compound-treated cells increased when compared to vehicle-treated cells. EMBS-treated cells demonstrated the most prominent increase in caspase 8 activity and ESE-16-treated cells the most prominent increase in caspase 6 activity when compared to vehicle-treated cells. 2-Methoxyestradiol-bis-sulphamate-treated cells are illustrated in the figure as 2MEBM due to limited space. An asterisk (*) indicates a statistically significant P-value of <0.05 when compared to vehicle-treated cells.