Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Sep 5;8(9):e71935. doi: 10.1371/journal.pone.0071935

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Visagie et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Double immunoflourecence was conducted to determine the compounds' effect after 24 h on microtubule dynamics within HeLa cells. Tyrosinated (dynamic) microtubules are visualized as red, whereas the detyrosinated (stable or stabilized) microtubules are stained in green. The vehicle-treated cells (A) demonstrated an intact dynamic microtubule structure. Both the colchicine positive control (B), as well as the ESE-16-treated cells (C) showed complete microtubule depolymerisation with few detyrosinated microtubule fragments remaining. ESE-15-one-treated cells (D) demonstrated altered microtubule morphology. EMBS-exposed cells (E) revealed fragmented microtubules. All treated cell samples demonstrated a decrease in cell density and rounded cells (X63 oil objective).