Figure 10. Sequence alignment and annotated tertiary motifs in c-di-GMP riboswitches.
(A) Sequence alignment of c-di-GMP riboswitches where gray shaded columns indicate the highly conserved nucleotide positions. Other color shaded columns indicate regions involved in tertiary interactions (brown: A-minor and yellow: loop-receptor interaction). For clarity, not all tertiary motif positions are numbered. Base-triple positions that are not conserved are in cyan shaded columns. (B) Tertiary structure of V. cholerae c-di-GMP riboswitch [27] (PDB ID = 3mxh). The ligand is represented as spheres and the highly conserved nucleotides are in wire representation. Magnification of the triple using numbering for 3mxh is presented in blue (A95-G14-C93).
