Figure 3. Neural inertia is affected by sleep homeostasis but not by mutations that exclusively impair non-homeostatic (baseline) sleep control or circadian clock function.

(a) Induction (solid) and emergence (dashed) curves for pdf⁰¹ mutants (red) and controls (black). (b) Induction (solid) and emergence (dashed) curves for cyc⁰¹ mutants (red) and controls (black). (c) Measurements of neural inertia do not vary significantly between pdf⁰¹, cyc⁰¹, Clk^jrk, DAT^fmn mutants (red) and their respective sibling controls (black). (d) Induction (solid) and emergence (dashed) curves for DAT^fmn mutants (red) and controls (black). (e,f) Dose-response curve for anesthesia emergence is left-shifted (dashed) without a change in anesthesia induction (solid) following 24 hrs sleep deprivation (red, dep; black, control), leading to an increase in neural inertia. n.s., not significant compared to control (one-way ANOVA with post-test Bonferroni correction), ** p<.001 by unpaired two-tailed t-test.