Table 1. Both HAP and PmCDA1 induce significantly more mutants than expected in diploid strains.

Strain	Ploidy, repair defect	Mutagen	Mutation frequency ×10−6  a	Fold increaseb
Canavanine resistance
LAN201	1n	-	1.1 (0.8–1.9)	1
LAN201	1n	HAP	25.1 (21.1–30.2)	23
LAN211	2n	HAP (predicted)	0.0006	0.0006
LAN211	2n	HAP	0.5c (0.4–0.7)	0.46
LAN200	1n, ung1	-	7.2 (2.9–9.8)	1
LAN200	1n, ung1	PmCDA1	159 (79–254)	22
LAN210	2n, ung1	PmCDA1 (predicted)	0.025	0.003
LAN210	2n, ung1	PmCDA1	2.3d (1.9–2.7)	0.32
5-FOA resistance
LAN200	1n, ung1	-	5.7 (4.1–9.1)	1
LAN200	1n, ung1	PmCDA1	264 (116–493)	46
LAN210	2n, ung1	PmCDA1 (predicted)	0.07	0.012
LAN210	2n, ung1	PmCDA1	2.7e (1.4–3.5)	0.47

^aMedian and 95% confidence limits.

^bWith respect to the corresponding haploid.

^c833× over predicted.

^d92× over predicted.

^e39× over predicted.