Figure 7. Pathoadaptive genes.
Genes identified from parallel evolution to be involved in host adaptation. Colors of squares denotes if the gene was mutated relative to the MRCA of the DK2 clones. Only genes mutated in any of the isolates from CF173 are shown (see full list of pathoadaptive genes in Table S2). The presence of mutations is shown for the first and last genotypes of each of the DK2 sub-lineages A, B, and C, which were observed to have infected patient CF173. The total sum of mutations observed within each of the genotypes is indicated at the top. Genes are grouped by function. Details about specific mutations and their fixation in the DK2 isolates are given in Table S5, Table S6, and Figure S4.
