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. 2013 Sep 5;8(9):e72907. doi: 10.1371/journal.pone.0072907

Figure 4. Age of onset of toxic RNA expression affects DM1 disease phenotypes.

Figure 4

RNA toxicity animals were compared to control groups for both A) PR interval and B) grip strength. Effects on grip strength and PR interval were more severe in the early induction mice (EDM1) compared to the adult onset mice (Adult-onset DM1). Averages are listed in the tables below the graphs. Error bars are SEM. Groups that do not share a letter are significantly different (p<0.05) using a One-Way ANOVA with Tukey’s Multiple Comparisons. N = 10 or more for each control group used to generate the control average and N = 17 or more for each DM1 group.