Table 2. Liver fold-change in mRNA accumulation during heat stroke recovery in WT and TNFR KO mice for HSP, cytokines, and cytokine receptors.

Gene	Strain	TC,max	RTB	Hypothermia
HSP70	B6129F2	657.9	780.4 †	1204.5 † §
	TNFR KO	565.8	783.2 †	1071.1 † §
IL-1	B6129F2	2.0 a	3.0 a	2.1
	TNFR KO	1.4§ a	1.6 † a	3.7 †
IL-1	B6129F2	2.6 a	10.7 † a	4.7
	TNFR KO	2.2 a	4.7 † a	7.0 †
IL-1RI	B6129F2	3.1	3.0	9.0 † §
	TNFR KO	3.0	2.9	4.7 †
IL-1RII	B6129F2	0.6a	1.9 a	9.4 † §
	TNFR KO	0.5a	0.8† a	6.3 † §
IL-6	B6129F2	1.1§ a	14.9 † a	2.7 § a
	TNFR KO	0.9§ a	6.7 † a	6.4 † a
IL-6R	B6129F2	1.2	1.1	1.7 §
	TNFR KO	1.2	1.2	1.4 †
gp130	B6129F2	1.4	1.0	1.5
	TNFR KO	1.2	1.4	1.2
IL-10	B6129F2	1.0	11.3 † a	14.0 †
	TNFR KO	1.1	4.6 † a	19.3 † §
TNF-	B6129F2	0.4	2.0†	1.1†
	TNFR KO	0.5	0.7	0.8

Data represent fold-change in liver mRNA accumulation relative to controls at the same time point. Bold fonts represent significantly higher than time-matched controls (one-way ANOVA, P);

^†represents significant difference from T;

^§represents significant difference from return-to-baseline;

^arepresents significant difference between genotypes within each gene. T, maximum core temperature (42.4°C); TNFR KO, tumor necrosis factor receptor knockout; WT, wild-type strain (B6129F₂).