Tabel 2.
Comparison of demographic information, mean deviation on standard automated perimetry, mean retinal nerve fiber layer thickness, and estimated retinal ganglion cell losses (estimated using the combined structure function index) for healthy and glaucomatous subjects (those with visible localized retinal nerve fiber layer defects) (n = 193 subjects, 264 eyes).
| Healthy Eyes = 198 Subjects = 138 |
Visible localized RNFL defect Eyes = 66 Subjects = 55 |
P Value | |
|---|---|---|---|
| Age (years)a | 62.5 (55.7 to 69.5) | 63.4 (56.1 to 71.6) | 0.248c |
| Race | 0.001d | ||
| White = 0 | 0 = 126 | 0 = 27 | |
| Black = 1 | 1 = 72 | 1 = 39 | |
| Mean Deviation (dB) | -0.1 (-1.0 to 1.0) | -3.3 (-5.9 to -1.4) | <0.001c |
| Mean RNFL thickness (um) | 96.3 ± 10.2 | 76.0 ± 12.9 | <0.001b |
| Estimated number of RGCs | 968,883 ± 170,230 | 657,172 ± 163,599 | <0.001b |
| Global CSFI (%) | 1 ± 13 | 39 ± 15 | <0.001b |
| CSFI1 (%) | 4 ± 19 | 10 ± 27 | 0.027b |
| CSFI2 (%) | 1 ± 21 | 13 ± 31 | 0.007b |
| CSFI3 (%) | -2 ± 22 | 30 ± 22 | <0.001b |
| CSFI4 (%) | -1 ± 20 | 19 ± 23 | <0.001b |
| CSFI5 (%) | 2 ± 28 | 16 ± 30 | 0.012b |
| CSFI6 (%) | 3 ± 27 | 4 ± 34 | 0.985b |
| CSFI7 (%) | 2 ± 23 | 26 ± 28 | <0.001b |
| CSFI8 (%) | -1 ± 18 | 52 ± 24 | <0.001b |
| CSFI9 (%) | 2 ± 21 | 52 ± 26 | <0.001b |
| CSFI10 (%) | 3 ± 16 | 19 ± 42 | 0.004b |
RNFL = retinal nerve fiber layer; dB = decibels; RGCs = retinal ganglion cells; CSFI = combined structure function index; CSFI1 to CSFI10 = combined structure function index in each sector (1 to 10) of the structure function map.
a
Median (interquartile range)
b
t-test
c
Wilcoxon-Rank sum test
d
Chi-square test