Table 2.

Safety data for cisplatin and doxorubicin

Parameter	Cisplatin	Doxorubicin
CAS-/EG no.	15663-27-1/239-733-8	23214-92-8/245-495-6
		25316-40-9/246-818-3 (hydrochloride)
Formula
Molecular weight	300.06 g/mol	543.52 g/mol
Melting point	270 °C; dark yellow powder at room temperature	205 °C (degradation); crystalline red powder at room temperature
Boiling point	Not applicable	Not applicable
Steam pressure	Not applicable	Not applicable
Water solubility	2.530 g/L (25 °C)	0.0928 g/L (25 °C)
LD50 oral	20 mg/kg (rat)	570 mg/kg (mouse)
	32 mg/kg (mouse)	–
NOAEL	No data	No data
Important toxicological details	Acute toxicity: very toxic Skin and eye irritation No evidence for transdermal absorption Cumulative damage of kidney, bone marrow, and inner ear No evidence of carcinogenicity in human Evidence for carcinogenicity and teratogenicity in mouse and rat Level of carcinogenicity: 2A Anaphylactic reactions reported Sensibilization of skin and airways	Acute toxicity: harmful Dilatative cardiomyopathy Inflammation of mucosa Leucopenia Evidence for carcinogenicity in animals Evidence for mutagenicity in animals Level of carcinogenicity 2A
Total amount applied	15 mg in 150 ml NaCl 0.9 %	3 mg in 150 ml NaCl 0.9 % solution
Concentration of applied solution	0.1 mg/ml = 0.1 g/L = 0.01 %	0.02 mg/ml = 0.02 g/L = 0.002 %
Workplace exposure limits	Germany: not available	Germany no upper legal limit
	Netherlands: 0.00005 mg/m3	–