Table 3. Roles of oxidative stress in HIE.
| Mediators | Investigated objects | Stimulation | Expression after stimulation | Effects on HIE | Compared to adults | References |
|---|---|---|---|---|---|---|
| H2O2 | P7 rats | HIE | Up-regulation | Detrimental | Higher | 161 |
| hSOD1-Tg P7 mice | HIE | Up-regulation | Detrimental | N/A | 163 | |
| COX-2 | P7 rats | HIE+LPS | Up-regulation | Correlated | N/A | 167 |
| NO | P7 rats | HIE+LPS | Up-regulation | Correlated | N/A | 167 |
| P7 rats | HIE | Up-regulation | Detrimental | N/A | 168 | |
| P7 rats | HIE | Up-regulation | Detrimental | N/A | 169 | |
| Tyrosine nitration | P1–3 piglets | HIE+iNOS inhibitor | Down-regulation | Detrimental | N/A | 170 |