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. 2013 Sep 6;7:539. doi: 10.3389/fnhum.2013.00539

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Copyright © 2013 Marangolo, Fiori, Calpagnano, Campana, Razzano, Caltagirone and Marini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Axial views of color coded probability map of lesion overlap (range 1% purple to 91% white). Individual volume lesions were drawn manually on the re-oriented brain volume transformed into MNI standardized stereotaxic coordinate system using a computational semi-automatic procedure of REGISTER software provided by Brain Imaging Center, Montreal Neurological Institute, McGill University. Averaging the labeled voxels of the individual lesion volumes re-aligned in MNI space generated the probability map revealing the localization of areas of percentage of lesion overlap. Maximal overlap includes the capsula estrema, the claustrum, part of the capsula esterna and the putamen. The inferior frontal gyrus (including the Broca's area) and the superior temporal gyrus (including the Wernicke's area) were similary damaged both having about 45% of lesion overlap.