Table 1. Physiologic parameters.
| Baseline | End HS | End Pre-hospital | End hospital | |
|---|---|---|---|---|
| Brain temperature (°C) | ||||
| PNPH | 37.37±0.10 | 37.39±0.13 | 37.36±0.12 | 37.19±0.06 |
| LR | 37.37±0.05 | 37.39±0.05 | 37.36±0.05 | 37.19±0.05 |
| pH | ||||
| PHPN | 7.35±0.01 | 7.30±0.03 | 7.41±0.01 | 7.30±0.01 |
| LR | 7.34±0.01 | 7.26±0.04 | 7.37±0.01 | 7.27±0.02 |
| pCO2 (mm Hg) | ||||
| PHPN | 40.87±1.76 | 24.63±0.74 | 34.18±1.51 | 48.01±1.26 |
| LR | 43.49±1.33 | 26.36±2.47 | 37.92±1.24 | 49.83±3.22 |
| pO2 (mm Hg) | ||||
| PHPN | 141.60±5.7 | 99.59±1.87 | 87.63±2.62 | 506.90±5.98 |
| LR | 149.50±2.67 | 100.79±1.43 | 82.54±2.40 | 494.11±16.43 |
| Oxygen saturation (%) | ||||
| PHPN | 97.81±0.43 | 94.43±0.80 | 98.82±0.58 | 100.0±0 |
| LR | 98.14±0.18 | 90.92±2.34 | 94.85±0.94 | 99.74±0.26 |
| Hematocrit (%) | ||||
| PHPN | 43.83±0.48 | 26.99±2.32 | 20.39±0.64 | 28.20±0.59 |
| LR | 43.60±0.28 | 29.29±0.57 | 19.75±0.62 | 28.98±0.60 |
| Hemoglobin (g/dL) | ||||
| PHPN | 14.29±0.16 | 9.46±0.30 | 6.64±0.20 | 9.20±0.19 |
| LR | 14.15±0.08 | 9.59±0.18 | 6.42±0.20 | 9.45±0.20 |
| Base excess (mEq/L) | ||||
| PHPN | −2.65±0.40 | −12.91±0.84 | −1.74±0.46 | −2.43±0.37 |
| LR | −2.34±0.21 | −14.64±1.37 | −2.98±0.61 | −4.26±0.83 |
| Bicarbonate (mmol/L) | ||||
| PHPN | 20.15±2.04 | 12.29±0.53 | 22.82±0.47 | 23.72±0.37 |
| LR | 23.82±0.41 | 11.17±0.89 | 22.01±0.61 | 22.35±0.71 |
| Sodium (mmol/L) | ||||
| PHPN | 146.70±0.62 | 142.30±0.72 | 145.00±0.45 | 145.40±0.43 |
| LR | 147.60±0.45 | 146.60±0.39 | 141.50±0.27 | 141.90±0.38 |
| Potassium (mmol/L) | ||||
| PHPN | 4.64±0.08 | 6.25±0.18 | 4.79±0.11 | 4.68±0.07 |
| LR | 4.72±0.06 | 6.36±0.20 | 5.10±0.21 | 5.19±0.22 |
| Chloride (mmol/L) | ||||
| PHPN | 116.04±0.56 | 118.80±0.99 | 123.90±2.96 | 120.20±0.47 |
| LR | 116.60±0.50 | 119.10±0.60 | 117.10±0.46 | 117.10±0.38 |
| Calcium (mmol/L) | ||||
| PHPN | 1.14±0.03 | 1.11±0.02 | 1.13±0.03 | 1.08±0.03 |
| LR | 1.17±0.02 | 1.13±0.03 | 1.12±0.02 | 1.03±0.05 |
| Glucose (mg/dL) | ||||
| PHPN | 262.50±11.15 | 420.90±33.31 | 166.00±30.02 | 126.00±3.31 |
| LR | 228.50±11.42 | 359.50±23.37 | 143.60±16.43 | 129.10±11.91 |
| Lactate (mmol/L) | ||||
| PHPN | 2.31±0.24 | 8.56±0.81 | 1.70±0.08 | 1.19±0.06 |
| LR | 2.18±0.13 | 10.07±1.19 | 2.23±0.31 | 1.43±0.25 |
| Osmolality (mmol/kg) | ||||
| PHPN | 307.30±0.63 | 306.42±1.69 | 297.61±1 | 297.77±0.98 |
| LR | 307.72±0.69 | 308.00±1.79 | 290.86±0.84 | 290.29±1.28 |
| Methemoglobinemia (%) | ||||
| PHPN | 0±0 | 0±0 | 4.64±0.27 | 1.44±0.18 |
| LR | 0±0 | 0±0 | 0.05±0.02 | 0±0 |
Abbreviations: HS, hemorrhagic shock; LR, lactated Ringer's; PNPH, polynitroxylated-pegylated hemoglobin.
All values are mean±standard error of the mean.