Table 5. Effect of progesterone on standardized total lesion volume, excluding animals that died, using individual animal data overall and in predefined subgroups.
| Model | SMD | 95% CI | Effect P | Interaction P |
|---|---|---|---|---|
| Overall, adjusted | −0.585 | −0.954, −0.215 | 0.004 | NA |
| Species, mice versus rats | −0.031 | −0.540, 0.478 | 0.90 | NA |
| Age, Aged versus young | −0.037 | −0.616, 0.541 | 0.90 | NA |
| Sex, adult female versus male versus aged females | 0.130 | −0.445, 0.706 | 0.87 | NA |
| Model, permanent versus transient | 0.004 | −0.535, 0.543 | 0.99 | NA |
| Time to treatment (per hour) | −0.001 | −0.005, 0.003 | 0.58 | NA |
| Loading dose (per mg/kg) | 0.011 | −0.006, 0.028 | 0.20 | NA |
| Total dose (per mg/kg) | −0.001 | −0.005, 0.004 | 0.80 | NA |
| Anesthetic (halothane versus isoflurane) | −0.000 | −0.589, 0.588 | 1.00 | 0.80 |
Abbreviations: CI, confidence interval; NA, not appropriate; SMD, standardized mean differences.
Data are SMD, 95% CI, and significance for effect and interaction. Analyses are adjusted for random effects and maintenance dose of progesterone. Result in bold are statistically significant.