Table 6. Effect of progesterone on death using individual animal *and summary* data overall and in predefined subgroups.
| Model | OR | 95% CI | Effect P | Interaction P |
|---|---|---|---|---|
| Overall, adjusted | 2.64 | 1.17–5.97 | 0.020 | NA |
| Species, mice versus rats | 10.35 | 2.14–49.93 | 0.004 | 0.028 |
| Age, aged versus young | 11.70 | 1.70–80.20 | 0.012 | 0.76 |
| Sex, adult female versus male versus aged females | 11.68 | 1.79–76.34 | 0.028 | ND |
| Model, transient versus permanent | — | — | NA | ND |
| Time to treatment (per hour) | 1.01 | 1.00–1.01 | 0.025 | NA |
| Loading dose (per mg/kg) | 0.89 | 0.69–1.15 | 0.36 | NA |
| Total dose (load+maintenance, per mg/g) | 1.03 | 0.99–1.06 | 0.16 | NA |
| Anesthetic, halothane versus isoflurane | 1.11 | 0.25–4.97 | 0.89 | NA |
Abbreviations: CI, confidence interval; NA, not appropriate; ND, Not done—no deaths in a comparator group; OR, odds ratio.
Data are OR, 95% CI, and significance for effect and interaction. Analyses are adjusted for random effects and species, age, sex, model, time to treatment, loading dose, total dose, and anaesthetic agent. Result in bold are statistically significant.