. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Int J Immunopathol Pharmacol. 2013 Jan-Mar;26(1):37–48. doi: 10.1177/039463201302600104

Table I.

Correlations among mediators of arthritic inflammation and bone remodeling

		Mediators of bone damage			Cytokines				Chemokines				Arthritic score
		RANKL	OPG	GM-CSF	TNF-α	IL-6	IL-17	IL-18	RANTES	MCP-1	MIP1-α	GRO/KC	Arthritic score
Mediators of bone damage	RANKL		-	+	+	+	+	+	+	NS	+	+	+
	OPG	-		-	-	NS	NS	-	-	NS	NS	-	-
	GM-CSF	+	-		+	NS	NS	+	+	NS	+	+	+
Cytokines	TNF-α	+	-	+		+	+	+	+	NS	+	+	+
	IL-6	+	NS	NS	+		+	+	+	+	+	+	NS
	IL-17	+	NS	NS	+	+		+	+	+	+	+	NS
	IL-18	+	-	+	+	+	+		+	NS	+	+	+
Chemokines	RANTES	+	-	+	+	+	+	+		NS	+	+	+
	MCP-1	NS	NS	NS	NS	+	+	NS	NS		+	NS	NS
	MCP-1α	+	NS	+	+	+	+	+	+	+		+	NS
	GRO/KC	+	-	+	+	+	+	+	+	NS	+		+

+, positive correlation (p< 0.05); -, Negative correlation (p< 0.05); NS, not significant (p> 0.05)