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. Author manuscript; available in PMC: 2014 Jan 11.
Published in final edited form as: Biochem Biophys Res Commun. 2012 Dec 10;430(2):494–499. doi: 10.1016/j.bbrc.2012.12.008

Figure 4.

Figure 4

A) Real Time PCR results in OA chondrocytes 24h post-transfection with NSC or Migfilin-specific siRNA. The diagram shows results for the genes: Migfilin (p= 0.00018), MMP-13 (p=0.027), collagen 10A1 (p=0.001), aggrecan (p=0.03), collagen 2A1 (p=0.0014) and β-catenin (p=0.033). Diagrams are the result of 4 independent experiments performed in ducplicate from 5 different OA samples. Asterisk indicates a statistically significant difference (p <0.05). B) Indicative western blot showing Migfilin, β-catenin, and MMP-13 protein expression in OA chondrocytes following Migfilin depletion. β-actin is used as loading control.