Table 8.

Comparison of QTL of FST behavior with mouse QTL for behavioral despair and emotionality and with human genetic linkage to depressive disorders

QTL	Mouse despair	Mouse/rat/emotionality	Human EOR-MDa	Human bipolar	Human anxiety disorder
Imm1 D2Rat188		DB latency to bury: D2Rat188 (Ahmadiyeh et al. 2004)		5q11 interacts with 6q24 (McInnis et al. 2003)
Imm2 D3Rat71			15q13.1 (Zubenko et al. 2002)
Imm3 D5Rat40	TST: Chr/4: 68.1 cM (Turri et al. 2001a; Yoshikawa et al. 2000)			1p33–66 (Cichon et al. 2001)
Imm6 D16Arb5		“Anxiety”: Chr 14: 16–20 cM (Henderson 2004)		3p21(Kelsoe et al. 2001)
Climb1 D1Rat246				6q21–22 (Cichon et al. 2001), 6q24 interacts with 5q11 (McInnis et al. 2003)
Climb2 D1Rat147		“Anxiety”: Chr 7: 56–70 cM (Henderson 2004)		11p15.5 (Muglia et al. 2002; Zandi et al. 2003)
Climb3 D2Rat220				3q26–27 (Cichon et al. 2001), 3q27 (Kelsoe et al. 2001)
Climb4 D3Rat181				2q21–33 (Cichon et al. 2001)
Climb5 D6Rat46		DB latency to bury: D6Rat46 (Ahmadiyeh et al. 2004); EPM D6Mit1 (Ramos et al. 1999)		2p24–21 (Cichon et al. 2001)
Climb6 D15Rat1		OFT a repeated saline injection: Chr 14: 3 cM (Boyle and Gill 2001)
FST1 D16Rat75				8p21 (Cichon et al. 2001)	8p21–22 (Cloninger et al. 1998)

^aEarly-Onset Recurrent Major Depression.