Table 1.

 

Select component	Phase(s)	Cellular expression	Key growth factor(s)	Function
Collagen I	Hemostasis Inflammatory Tissue formation Tissue remodeling	Epithelial, endothelial, fibroblast, smooth muscle, leukocytes, platelets	bFGF TGF-β PDGF EGF	Tissue architecture Tensile strength Cell–matrix and matrix–matrix interaction ECM remodeling
Collagen III	Hemostasis Inflammatory Tissue formation	Epithelial, endothelial, fibroblast, leukocytes, platelets	EGF TGF-β PDGF EGF	Tissue architecture Matrix–matrix interaction Maturation and ECM remodeling
Fibrinogen	Hemostasis Inflammatory Tissue formation	Platelets, leukocytes, endothelial, fibroblast	FGF-2 VEGF	Cell–cell interaction Cell–matrix Platelet–protein Cell proliferation Cell migration
Hyaluronan	Tissue formation Tissue remodeling	Epithelial, fibroblast, smooth muscle	TGF-β1 EGF Chemokines	Cell–matrix interactions Matrix–matrix interactions Cell proliferation Cell migration
Fibronectin	Hemostasis Inflammatory Tissue formation Tissue remodeling	Epithelial, endothelial, fibroblast, leukocytes, platelets	PDGF Chemokines	Tissue architecture Cell–matrix and matrix–matrix interactions Cell proliferation and migration Opsonin
Tenascin C	Tissue formation Tissue remodeling	Epithelial, fibroblast	EGF-like repeats TGF-β Chemokines	Modulates cell–matrix Anti-adhesive Anti-proliferative
Decorin	Tissue formation Tissue remodeling	Fibroblast	EGF TGF-β1 Chemokines	Cell–matrix interactions Matrix–matrix interactions Bind and storage of growth factors Cell proliferation
Entactin (or nidogen)	Hemostasis Inflammatory Tissue formation	Epithelial, fibroblast, neutrophil	EGF	Basement membrane component Stabilizes basement membrane
Laminin	Hemostasis Inflammatory Tissue formation Tissue remodeling	Epithelial, endothelial, fibroblast, smooth muscle, platelets, neutrophil, monocyte	EGF Chemokines	Basement membrane component Cell migration
Collagen IV	Tissue formation Tissue remodeling	Epithelial, endothelial, fibroblast, smooth muscle, platelets, neutrophil, monocyte	EGF Chemokines	Basement membrane component Cell migration