Table 1.

SIRT1 Targets in Multiple Signaling Pathways

Signaling pathways	Targets	Reference
Tumor suppressor	p53, p73, and HIC1	13-16
Energy homeostasis	FOXO1, FOXO3a, and FOXO4	17-19
	PGC1α, PPARγ, and AceCS1	22-28
Autophagy	Atg5, Atg7, and Atg8	56
Hypoxia-inducible factors	HIF-1α and HIF-2α	29-31
PI3K/AKT pathway	PTEN	32
TGF-β signaling pathway	Smad3 and Smad7	33, 34
Wnt signaling pathway	β-catenin, DKK1, and Dvls	35, 36, 72
NF-κB signaling	RelA/p65	20, 21, 76
DNA damage repair pathway	Ku70, XPA, XPC, and NBS1	37-40