Table 1.

The Gene Products That Have Been Established as Acetylated Proteins Capable of Being Deacetylated by SIRT1 Either In Vivo, In Vitro, or Both

SIRT1 substrates
14-3-3ξ146	c-JUN65	HIF1α147	MeCP2148	PDK1149	STAT3150
Ac-CoA synthase151	c-MYC83	HIF2α152	MEF2D153	PER237	SUV39H1154
AKT149	Cortactin31	Histone H1155	MMP2156	PGAM1157	SV40 Tag158
APE1159	CREB160	Histone H34	MYST222	PGC1α47,161	TAT (HIV)162
AR135	DNMT1163	Histone H44	NBS1164	PGC1β165	Tau166
ATG530	eNOS167	HMGSC1168	NF-κB (p65)169	PIP5Kγ170	TIP5 (NCoR)171
ATG730	ERRα172	hMOF25	NHLH2173	PPARγ174	TIP6025,175
ATG830	FOXO1176	HNF4α177	NID178	PTEN179	TORC1180
β-catenin144	FOXO3A181	HSF1182	Nrf2183	RARβ184	WRN185
BCL6186	FOXO4187	IRS2117,188	p30023,181	RB189	XBP190
BMAL138	FOXP3191	Ku70126,192	p5326,27	SATB1193	XPA194
CBP22	FXR195	LKB1196	p73197	SMAD7198	YAP199
CIITA200	HIC1201	LXR202	PAX3203	SREBP1c204	Zyxin205
RFX5206

Note: Those proteins labeled in bold are normally cytoplasmic, while those not in bold are at least partially nuclear.