Table 1.
Selected Sirtuin Substrates
| HAT(s) | Sirtuin(s) | HAT(s) | Sirtuin(s) | ||
|---|---|---|---|---|---|
| Chromatin related | Metabolism | ||||
| p300 | p300 | SIRT1 | ACS1 | n.d. | SIRT1 |
| SIRT2 | |||||
| MOF | MOF | SIRT1 | ACS2 | n.d. | SIRT3 |
| Suv39h1 | n.d. | SIRT1 | PGC-1α | GCN5 | SIRT1 |
| EZH2 | n.d. | SIRT1 | LXR | n.d. | SIRT1 |
| Tip60 | Tip60 | SIRT1 | FXR | p300 | SIRT1 |
| Stress related | SREBP-1c | CBP/p300 | SIRT1 | ||
| p53 | CBP/p300 | SIRT1 | LKB1 | n.d. | SIRT1 |
| PCAF | SIRT2 | ||||
| Tip60 | SIRT3 | ||||
| FOXO1 | CBP | Sir2α (SIRT1) | PEPCK1 | p300 | SIRT2 |
| FOXO3a | CBP/p300 | SIRT1 | ALDH2 | n.d. | SIRT3 |
| SIRT2 | |||||
| FOXO4 | CBP/p300 | SIRT1 | Ndufa9 | GCN5 | SIRT3 |
| NF-κB | p300 | SIRT1 | SdhA | n.d. | SIRT3 |
| SIRT2 | |||||
| c-Fos | n.d. | SIRT1 | CPS1 | n.d. | SIRT5 |
| c-Jun | p300 | SIRT1 | GDH | n.d. | SIRT3 |
| SIRT4 | |||||
| c-Myc | PCAF | SIRT1 | Other | ||
| Tip60 | SIRT2 | ||||
| p300 | |||||
| HIF-1α | p300 | SIRT1 | CDH1 | n.d. | SIRT2 |
| SIRT6 | |||||
| E2F1 | PCAF | SIRT1 | CDC20 | n.d. | SIRT2 |
| Tip60 | |||||
| p300 | |||||
| DNA repair | Cyclophilin D | n.d. | SIRT3 | ||
| Ku70 | PCAF | SIRT1 | RIP1 | p300 | SIRT1 |
| CBP | SIRT3 | ||||
| XPA | CBP | SIRT1 | α-tubulin | α-TAT | SIRT2 |
| p300 | |||||
| CtIP | n.d. | SIRT6 | Cortactin | PCAF | SIRT1 |
| NBS1 | PCAF | SIRT1 | RAR-β | n.d. | SIRT1 |
| p300 | |||||
| PARP1 | p300/CBP | SIRT1 | Tau | p300 | SIRT1 |
| PCAF | |||||
Note: These are classified into chromatin-related, stress-related, DNA repair, metabolism, and other substrates. The sirtuins in charge of their deacetylation are indicated in the third column. The table also includes the histone acetyltransferases (HATs), also known as lysine acetyltransferases, responsible for the acetylation of each sirtuin substrate.92,96,98,102,103,106,113,114,122,125,152,155,175,182,184,192-201 n.d. = not determined.