Table 1.
Patient characteristics.
| Characteristics | No. (%) | NPM1 mut. no. (%) | NPM1 wt. no. (%) | P value |
|---|---|---|---|---|
| No. | 70 | 20 (29) | 50 (71) | |
| Median age, years (range) | 66 (23–87) | 64 (40–81) | 67 (23–87) | 0.58 |
| ≤60 | 23 (33) | 7 (35) | 16 (32) | 0.20 |
| >60 | 47 (67) | 13 (75) | 34 (68) | |
| AHD | 42 (60%) | 11 (55) | 31 (62) | 0.16 |
| Median WBC × 109/L (range) | 12.8 (0.3–245) | 10.7 (0.5–245) | 13.7 (0.3–196) | 0.13 |
| Median hemoglobin g/dL (range) | 7.8 (2.9–12.5) | 8.2 (6.9–12.5) | 7.8 (2.9–12.2) | 0.04 |
| Median platelets × 103/mL (range) | 55 (8–334) | 55 (12–275) | 55 (8–334) | 0.41 |
| Median BM blasts % (range) | 52 (11–94) | 54 (13–91) | 52 (11–94) | 0.68 |
| Treatment with ATRA | 0.11 | |||
| Yes | 36 (51) | 7 (35) | 29 (58) | |
| No | 34 (49) | 13 (65) | 21 (42) |
NPM1, nucleophosmin 1; wt, wild type; mut, mutated; AHD, antecedent hematologic disorder; WBC, white blood cell count; BM, bone marrow; ATRA, all-trans retinoic acid.