Table 3.
Coexisting Autoantibodies
| Antibody Type Specificity | Patients, No. | Median Values (Range), nmol/L |
|---|---|---|
| Neuronal cation channel | 19 | |
| Voltage-gated calcium channel | 13 | |
| N-type | 8 | 0.06 (0.03–0.15)a |
| P/Q-type | 5 | 0.07 (0.03–13)b |
| Voltage-gated potassium channel | 6 | 0.08 (0.03–0.46)b |
| Neuronal nuclear or cytoplasmic | 14 | |
| GAD65 | 11 | 0.14 (0.03–0.15)b |
| ANNA-1 | 2 | 15 360; 30 720c |
| CRMP-5 | 1 | Western blot positive |
| Skeletal muscle | 13 | |
| AChR | 10 | 2.87 (0.04–38.9)b |
| Striational | 3 | 480; 15 360; 30 720d |
Abbreviations: AChR, muscle acetylcholine receptor; ANNA-1, antineuronal nuclear antibody-1; CRMP-5, collapsin response-mediator protein-5; GAD65, 65kDa isoform of glutamic acid decarboxylase.
a
Normal values are 0.03 nmol/L or less.
b
Normal values are 0.02 nmol/L or less.
c
Normal values are negative at 1:240.
d
Normal values are negative at 1:60.