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. Author manuscript; available in PMC: 2014 Jun 27.
Published in final edited form as: Immunity. 2013 Jun 27;38(6):1092–1104. doi: 10.1016/j.immuni.2013.06.009

Figure 1. A Potential Role for Low-Density Lipoprotein as an Antigen that Promotes Atherosclerosis.

Figure 1

Native LDL can undergo slight oxidative modification that permits its uptake by PRRs on APCs (which may include DCs) but does not alter amino acid side chains in ApoB sufficiently to interfere with immunogenicity. The ApoB-derived proteins, presented in the context of self MHC, with appropriate costimulation, stimulate proliferation of the antigen-specific T cell clone and aggravation of atherogenesis.