Fig. 2.

Obesity in Clock mutant mice. (A) Energy intake. Average caloric intake over a 10 week period in male WT and Clock mutant mice. WT and Clock mutant mice were provided ad libitum access to regular (10% kcal/fat, WT, n=8, Clock, n=10) or high-fat chow (45% kcal/fat, WT, n=7, Clock, n=11) for 10 weeks beginning at 6 weeks of age. Weekly food intake was analyzed in the two groups (*, p<0.01). (B) Body weight. Body weights for the animals depicted in (A) after the 10 week study (*, p<0.01). (C) Longitudinal weight gain. Body weights WT (open) and Clock mutant (closed) mice over the 10 week study for animals depicted in (A) fed either regular (circle) or high fat (square) diets. (D) Post-weaning body weight of mice beginning at 10 days through 8 weeks of age. Growth curves in WT (open circle) and Clock mutant (closed circle) mice on regular chow were obtained by weighing animals weekly. Significant differences did not appear until 6 weeks of age (*, p<.05). All values (A–D) represent group means ± SEM