Fig. 2.
Schematic of the portion of the PG/COX pathway involved in the regulation of skeletal muscle protein metabolism and adaptation. See text for specific references related to the enzymes, intermediates, and receptors of the COX pathway, as well as the studies that have delineated the factors and cellular processes regulated by the PGE2 and PGF2α receptors that influence skeletal muscle mass. See Trappe et al. (127) for nomenclature related to the PG synthases, reductase, and receptors. MuRF-1, muscle RING finger protein-1; PI3K/ERK/mTOR, phosphoinositide 3-kinase/ERK/mammalian target of rapamycin (62).