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. 2013 May 20;591(Pt 16):3821–3832. doi: 10.1113/jphysiol.2012.250647

Figure 2. Effects of intracellular inhibitory and excitatory neurotransmitters on unitary inhibitory synaptic transmission.

Figure 2

A, effect of intracellular perfusion of GABA. Representative current traces showing the effect of SR95531 and strychnine at 5 min and 60 min after rupture of the patch membrane of a presynaptic cell, which was intracellularly perfused with pipette solution containing 100 mm GABA. B, effect of intracellular infusion of glutamate. In this case, SR95531 produced no detectable inhibition on the evoked IPSCs at 5 min after starting the recording. C, effect of intracellular perfusion of GABA, glutamate and glycine. Each panel shows the inhibitory action of SR95531 on unitary IPSCs at 5 min and 60 min after starting the recording. Concentration of each transmitter was 100 mm. Values obtained by one paired recording are filled circles connected by line. Open circles show mean ± SEM.