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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Cell Host Microbe. 2013 Aug 14;14(2):125–135. doi: 10.1016/j.chom.2013.06.008

Figure 2. Predicted model of MCV sT structure.

Figure 2

MCV sT protein structure based on the SV40 sT crystal structure (I-TASSER server) shown in both space-filling (A) and ribbon (B) representations. The latter reveals the conserved structures with overlapping regions for SV40 (green) and MCV (turquoise). PP2A binding (gold) and DnaJ (magenta) domains conserved for both viruses are shown. The MCV LSD (red) is a large unstructured loop on the opposite molecular face from the PP2A-binding domain that is foreshortened in SV40 (black). Amino acid alignment between MCV sT and SV40 sT (32.52% sequence identity) indicates (|) identical, (:) similar and (.) dissimilar residues and shows loss of homology in the region corresponding to the LSD. See also Movie S1.