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D4 activation exerts a bi-directional regulation of CaMKII activity in stressed animals. A, representative immunoblots of p-CaMKII and total CaMKII in lysates of PFC slices incubated without or with PD168077 (40 μm, 10 min) from nonstressed versus acutely or repeatedly stressed animals. B, quantification showing the percentage change of p-CaMKII by PD168077 in PFC slices from nonstressed versus stressed animals. *, p < 0.001, ANOVA. Error bars indicate mean ± S.E.
