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. 2013 Jul 23;288(36):26265–26274. doi: 10.1074/jbc.M113.476556

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Diminished phosphorylation of serine 390 of PR-A and inactive GSK-3β in the Brca1-deficient mammary gland. A, phosphorylation of serine 390 in PR-A and total PR-A levels in the mammary gland of Brca1/p53-conditional knock-out mice. Immunoblotting was performed using lysates prepared from mammary glands of mice at either estrous and diestrous cycle as indicated. Lane 1, WT diestrous; lane 2; WT estrous; lane 3, Brca1/p53 estrous; lane 4, Brca1/p53 diestrous. B, GSK-3β activity in the Brca1-deficient mammary gland. Immunohistochemistry was performed using paraffin-fixed mammary gland sections from wild-type, p53^f/f WapCre^c (p53), and Brca1^f/f p53^f/fWapCre^c (Brca1/p53) mice with antibodies against GSK-3β phosphoserine 9 (pSer 9) (top panel) and GSK-3β (bottom panel). p-PR, phosphorylated PR; wt, wild-type.