Table 1.
Candidate RNAi Treatments with Human Orthologs That Influence Ricin Toxicity
| Target Gene | Name | Human Ortholog | Candidate Role |
|---|---|---|---|
| z>3 | |||
| CG8428 | Spinster | Spinster homolog 1 | Endocytosis |
| 3>z>2 | |||
| CG11184 | Upf3 | UPF3 regulator of nonsense transcripts homolog B (yeast) | Gene silencing by miRNA |
| CG30429 | None | MORN repeat containing 3 | Not known |
| CG10302 | Bicoid stability factor | Leucine-rich PPR-motif containing | mRNA 3′-UTR binding |
| CG30338 | None | RWD domain containing 2B | Not known |
| CG31683 | None | Phospholipase A2, group XV | Phospholipase |
| CG10078 | Phosphoribosyl amidotransferase 2 | Phosphoribosyl pyrophosphate amidotransferase | Nucleoside metabolic process |
| CG5809 | CaBP1 | Protein disulfide isomerase family A, member 6 | Reduction of ricin intrachain disulfide |
| CG31787 | None | ERP2 (yeast) | ER-to-Golgi transport |
| CG3570 | None | UPF0532 protein C7orf60 | Not known |
| CG6699 | β′−coatomer protein | Coatomer protein complex, subunit beta 2 (beta prime) | ER-to-Golgi transport |
| CG8726 | None | PX domain containing serine/threonine kinase | Protein kinase |
| CG13708 | None | Leucine-rich repeat containing 49 | Not known |
| −2<z<−1 | |||
| CG3024 | Torp4a | Torsin family 1, member A (torsin A) | Chaperone-mediated protein folding |
| CG18654 | None | Diacylglycerol kinase, beta 90 kDa | Diacylglycerol kinase |
| CG5189 | None | Roadblock domain containing 3; Rab25 | Golgi apparatus; endosome? |
| CG2173 | Rs1 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | RNA helicase; ribosome biogenesis |
| CG3766 | Scattered | Vacuolar protein-sorting 54 homolog | Endosome/Golgi transport and sorting |
| CG33008 | None | Transmembrane protease, serine 4 | Serine-type endopeptidase |
| CG14396 | Ret oncogene | Ret proto-oncogene | Signal transduction |
| CG5403 | Retained | AT-rich interactive domain 3A (BRIGHT-like) | Transcription activator |
| CG15010 | Archipelago | F-box and WD repeat domain containing 7 | Ubiquitin-protein ligase |
| −3<z<−2 | |||
| CG4046 | Ribosomal protein S16 | Ribosomal protein S16 | Structural constituent of ribosome |
| CG11079 | None | 5,10-Methenyltetrahydro-folate synthetase (5-formyltetrahydrofolate cyclo-ligase) | Unknown |
| CG3029 | Orange | Adaptor-related protein complex 3, sigma 2 subunit | Intracellular protein transport |
Bold type indicates genes tested with two different RNAi molecules.