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. 2013 Aug 15;170(1):177–187. doi: 10.1111/bph.12170

Figure 4.

Figure 4

H3 receptor antagonists do not alter alcohol-induced locomotor stimulation in wild-type (WT; 129/Sv) or in histidine decarboxylase knock-out (HDC KO) mice. Pretreatment (saline, ciproxifan 3 mg·kg−1, JNJ-39220675 0.3 or 10 mg·kg−1, i.p.) was given after a 60–90 min habituation period and alcohol (1.5 g·kg−1, i.p.) was injected 30 min after the pretreatment. Alcohol induces stimulation in both genotypes. Alcohol-induced stimulation is not affected by the pretreatment with ciproxifan in WT (A) or in HDC KO (B) mice; n = 12–14 per group. Alcohol-induced stimulation is also not affected by the pretreatment with JNJ-39220675 in WT (C) or in HDC KO (D) mice; n = 8–9 per group. Two-way repeated measures anova, no interaction or treatment effect, significant time effect in all groups (P < 0.0001) indicating similar alcohol-induced stimulation regardless of pretreatments with H3 receptor antagonist. All data are expressed as mean ± SEM.