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Kaplan–Meier survival of xenografted nude mice against different H4R ligand treatments. Treatments were administered daily by sc injection of saline buffer for the control group, histamine (Ha, 5 mg kg−1), clozapine (Clz, 1 mg kg−1), JNJ28610244 (J28, 10 mg kg−1), 5 days a week until death (***P < 0.0005, Log rank test and Gehan-Breslow-Wilcoxon test).
