Figure 9.

Effect of H₄R and H₃R antagonists on MDA-MB-231 xenografted tumour into nude mice. Relative tumour volume of the control group versus (A) JNJ10191584 (JNJ1019, 10 mg kg⁻¹), (B) JNJ10181457 (JNJ1018, 10 mg kg⁻¹). Data are shown as means ± SEM. Tumour volumes were measured three times a week and a non-linear regression fit was performed to evaluate the exponential growth (**P < 0.01, ***P < 0.001, vs. Control; T-test). Kaplan–Meier survival of the control group versus (C) JNJ10191584 (JNJ1019, 10 mg kg⁻¹), (D) JNJ10181457 (JNJ1018, 10 mg kg⁻¹). (**P < 0.01, Log rank test and Gehan-Breslow-Wilcoxon test). (E) Median tumour doubling time, median survival and median number of lung metastases of each group are depicted numerically (^#P < 0.05, ^##P < 0.01 vs. Control).