Figure 3.

Astra-blue staining (A–F) and densitometric analysis (G) of lung mast cells. Compared with the controls (A,B), a prominent reduction of mast cells staining, directly related to granule discharge, is clearly visible in sections from the sensitized guinea pigs challenged with OA (C). These changes were significantly reduced in animals treated with JNJ at doses of 5, 7.5 and 10 mg·kg⁻¹ (D–G). Values are the mean ± SEM per group, n = 6. *P ≤ 0.05, significantly different from OA. Bars = 10 μm.