Figure 4.

eMBP immunostaining (A–F) and relative densitometric analysis (G); MPO activity quantification (H). The treatment with JNJ at doses of 5, 7.5 and 10 mg·kg⁻¹ body weight (D–F), attenuated the inflammatory response induced by OA challenge (C) in sensitized guinea pigs, reducing the number of eosinophils positive for eMBP (indicated by arrows) (G) and the activity of neutrophil marker MPO (H). Values are the mean ± SEM per group, n = 6. *P ≤ 0.001, significantly different from OA. Bars = 100 μm.