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Lung tissue levels of MDA (A) and 8-OHdG (B), key markers of oxidative injury, are significantly increased, while the activity of Mn-SOD (C) is significantly decreased in the sensitized guinea pigs challenged with OA, compared with the controls. Treatment with increasing doses of JNJ caused a significant, dose-related reversal of the noted parameters. Values are the mean ± SEM per group, n = 10. *P ≤ 0.01, ***P ≤ 0.001, significantly different from OA.
