Figure 7.

mRNA for lipocortin-1 and protein levels in lung tissue samples (A), assessed by RT-PCR and Western blotting, respectively, are significantly decreased in the sensitized guinea pigs challenged with OA, but not in those treated with 10 mg·kg⁻¹ JNJ. Similarly, lipocortin-1 levels immunodetected in BAL fluid (B) are markedly decreased in the sensitized guinea pigs challenged with OA, while JNJ at the doses of 7.5 and 10 mg·kg⁻¹ reversed such decreases. Values are the mean ± SEM per group, n = 6. *P ≤ 0.01, significantly different from OA.