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BAL levels of the pro-inflammatory cytokines TNF-α (A) and IL-4 (B), the chemoattractant LTB4 (C), and the mast cell-derived PGD2 (D) are significantly increased in the sensitized guinea pigs challenged with OA as compared with the controls. Treatment with increasing doses of JNJ caused a significant, dose-related reversal of the noted variables. Values are the mean ± SEM per group, n = 5. *P ≤ 0.001, significantly different from OA.
