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RT-PCR analysis for IL-4 and TNF-α mRNA performed in BAL fluid of guinea pigs from different experimental groups. The assayed pro-inflammatory cytokines are significantly up-regulated in the sensitized guinea pigs e challenged with OA, but not in those treated with 10 mg·kg−1 JNJ. Values are the mean ± SEM per group, n = 6. *P ≤ 0.01, significantly different from OA.
