Table 1.

Locomotor activity of an adult rat during exposure of a juvenile rat; effect of i.c.v. injection of thioperamide together with famotidine during the second exposure

	Control	Exposure
1. Exposure (n = 9)	2.88 ± 1.60	49.00 ± 13.85**
2. Second exposure after 60 min (n = 5)	1.80 ± 1.11	9.20 ± 4.09*,++
3. Second exposure after 90 min (n = 9)	0.40 ± 0.20	38.30 ± 13.37**,¶
4. Second exposure after 90 min + vehicle (n = 9)	0.62 ± 0.32	39.40 ± 14.41**,¶
5. Second exposure after 90 min + Thio + Fam (n = 7)	1.00 ± 0.68	28.00 ± 13.95**,¶

Control, locomotor activity 10 min prior to exposure; Thio, thioperamide (i.c.v., 5 μg); Fam, famotidine (i.c.v., 20 μg); vehicle (aCSF). Intracerebroventricular injection of the compounds was carried out immediately after the first exposure. Each exposure lasted 10 min. Mean values ± SEM. Number of experiments is shown in parentheses. *P < 0.05, **P < 0.01, significantly different from control (Wilcoxon's rank test). ⁺⁺P < 0.01, 2 significantly different from 1, 3, 4 and 5. ^¶ values for conditions 3, 4 and 5 were not significantly different from each other. (Mann–Whitney U-test).