Table 2.
Changes in Cognitive Performance by Treatment Group and Diagnosisa
| Test | z Score, Mean (SE)
|
|||
|---|---|---|---|---|
| GHRH Group
|
Placebo Group
|
|||
| Normal Cognitive Function | MCI | Normal Cognitive Function | MCI | |
| Executive function composite | 0.39 (0.24) | −0.07 (0.19) | −0.09 (0.11) | −0.42 (0.13) |
| Task-switching accuracy | 0.61 (0.18) | 0.11 (0.16) | −0.18 (0.24) | −0.75 (0.37) |
| Stroop interference RT | 0.30 (0.18) | −0.23 (0.47) | −0.18 (0.18) | −0.56 (0.29) |
| SOPT accuracy | 0.51 (0.32) | 0.11 (0.28) | 0.27 (0.39) | −0.17 (0.36) |
| Word fluency | 0.22 (0.43) | −0.29 (0.41) | −0.29 (0.31) | −0.22 (0.27) |
| Verbal memory composite | 0.39 (0.45) | 0.21 (0.25) | 0.16 (0.20) | −0.48 (0.17) |
| Story total recall | 0.40 (0.44) | 0.44 (0.42) | 0.33 (0.26) | −0.25 (0.23) |
| HVLT total recall | 0.37 (0.48) | −0.02 (0.45) | −0.004 (0.32) | −0.71 (0.27) |
Abbreviations: GHRH, growth hormone–releasing hormone; HVLT, Hopkins Verbal Learning Test; MCI, mild cognitive impairment; RT, reaction time measured using voice onset latency; SOPT, Self-ordered Pointing Test.
a
Values represent mean changes in performance, expressed as z scores of residualized change scores, by treatment assignment and diagnosis at week 20 relative to baseline. The z scores are unadjusted for covariates that were included in the model (age, educational level, and baseline Mini-Mental State Examination score).