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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: J Med Chem. 2012 Oct 8;55(20):8807–8826. doi: 10.1021/jm3011146

Scheme 2.

Scheme 2

Synthesis of des-chlorinated compound 2, ester 3 and amides 4a

a Reagents and conditions: (a) H-Cube, H2, 10 % Pd/C, EtOH, EtOAc, 60 °C, 40 %; (b) MeOH, H2SO4, rt, 12 h, quant; (c) CDI, pyridine, 60 °C, 12 h, 85-86 %.