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SAR exploration around 15ca
| ||||
|---|---|---|---|---|
| Compd | R | IC50 (μM)
± SDb
|
||
| FAAH | COX-1 | COX-2 | ||
| 15c |
|
22.0±4.2 | 74.3±28.0 | 72.3±28.0 |
| 15d |
|
30.9±10.6 | / | / |
| 15e |
|
10.6±2.6 | / | / |
| 15f |
|
20.1±2.6 | / | / |
| 15g |
|
59.6±15.5 | / | / |
| 15h |
|
/ | / | / |
| 15i |
|
84.8±10.6 | 30.0±12.1 | 27.8±9.7 |
| 15j |
|
5.6±2.9 | 12.8±8.9 | / |
| 15k |
|
/ | / | / |
Values are means of ≥3 experiments performed in duplicate;
/ : IC50 >100μM
