Table 3.

FAAH, COX-1 and COX-2 activities of single enantiomers of compounds 1, 15c and 15i ^a

Compd	IC50 (μM) ± SDb
	FAAH	COX-1	COX-2
(±)-1	78.6±19.7	22.3±6.6	3.9±1.0
S-(+)-1	64.2±3.6	5.6±0.1	5.3±3.0
R-(-)-1	/	/	/
(±)-15c	22.0±4.2	74.3±28.0	72.3±28.0
S-(+)-15c	/	45.0±0.3	46.5±4.3
R-(-)-15c	14.9±1.6	/	/
(±)-15i	84.8±10.6	30.0±12.1	27.8±9.7
S-(+)-15i	/	4.1±2.8	2.5±1.4
R-(-)-15i	53.2±22.6	/	/

^aValues are means of ≥3 experiments performed in duplicate;

^b/ : IC₅₀ >100μM