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Alcohol enhances SERT function. Dendritic cells (DC) were treated with 0.1% alcohol both in the presence and absence of imipramine for 24 hours. The cells were incubated with 4-[4-(dimethylamino)-styryl]-1-methylpyridinium iodide (ASP) and the uptake of ASP by DC was measured. The ASP fluorescence intensity was higher in alcohol-treated DC. Imipramine treatment lowered the uptake of ASP by DC.
