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HCV is an enveloped, positive-stranded RNA virus. The 9.6 kilo base (kb) genome is translated into a single polyprotein precursor of approximately 3000 amino acids. Cleavage of the polyprotein by viral and host-cell proteases yields structural viral proteins (core protein and envelope proteins E1 and E2) and nonstructural viral proteins (NS2 through NS5B), with a number of putative activities and functions.
